![]() ![]() Furthermore, tuft cells were also observed upon bleomycin injury, suggesting that their development may be a general response to severe lung injury. Distinct from intestinal tuft cells which rely on Type 2 immune signals for their expansion, neither IL-25 nor IL-4Rα signaling are required to drive tuft cell development in dysplastic/injured lungs. Using bulk and single cell transcriptomics, we characterized and delineated multiple distinct tuft cell populations that arise following influenza clearance. We recently described the emergence of tuft cells within Krt5 + dysplastic regions after influenza injury. The connection between these enduring changes and chronic disease remains poorly understood. ![]() While the lung bears significant regenerative capacity, severe viral pneumonia can chronically impair lung function by triggering dysplastic remodeling. ![]()
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